-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, WXMrwCspJQSAUjYDKOTxqVnHJIUUba10cFHjI6pSKHMaG8YUv1UyVWmkJzRoYUVT FFY1Cwllw/6GlshpIDUuDg== 0000950116-97-000278.txt : 19970222 0000950116-97-000278.hdr.sgml : 19970222 ACCESSION NUMBER: 0000950116-97-000278 CONFORMED SUBMISSION TYPE: SC 13G PUBLIC DOCUMENT COUNT: 1 FILED AS OF DATE: 19970214 SROS: NONE GROUP MEMBERS: HAROLD R. WERNER GROUP MEMBERS: HEALTHCARE PARTNERS III, L.P. GROUP MEMBERS: HEALTHCARE PARTNERS IV, L.P. GROUP MEMBERS: HEALTHCARE VENTURES III L P GROUP MEMBERS: HEALTHCARE VENTURES IV, L.P. GROUP MEMBERS: JAMES H. CAVANAUGH, PH.D. GROUP MEMBERS: JOHN W. LITTLECHILD GROUP MEMBERS: WILLIAM CROUSE SUBJECT COMPANY: COMPANY DATA: COMPANY CONFORMED NAME: HUMAN GENOME SCIENCES INC CENTRAL INDEX KEY: 0000901219 STANDARD INDUSTRIAL CLASSIFICATION: IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835] IRS NUMBER: 223178468 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G SEC ACT: 1934 Act SEC FILE NUMBER: 005-45295 FILM NUMBER: 97532916 BUSINESS ADDRESS: STREET 1: 9410 KEY WEST AVENUE CITY: ROCKVILLE STATE: MD ZIP: 20850-3331 BUSINESS PHONE: 3013098504 MAIL ADDRESS: STREET 1: 9410 KEY WEST AVE CITY: ROCKVILLE STATE: MD ZIP: 20850 FILED BY: COMPANY DATA: COMPANY CONFORMED NAME: HEALTHCARE VENTURES III L P CENTRAL INDEX KEY: 0000886425 STANDARD INDUSTRIAL CLASSIFICATION: UNKNOWN SIC - 0000 [0000] IRS NUMBER: 223161305 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G BUSINESS ADDRESS: STREET 1: TWIN TOWERS AT METRO PARK STREET 2: 379 THORNALL AVENUE CITY: EDISON STATE: NJ MAIL ADDRESS: STREET 1: TWIN TOWERS AT METRO PARK STREET 2: 379 THORNALL AVENUE CITY: EDISON STATE: NJ ZIP: 0887 SC 13G 1 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* HUMAN GENOME SCIENCES, INC. ----------------------------------------------------------------- (Name of Issuer) Common Stock $.01 par value ----------------------------------------------------------------- (Title of Class of Securities) 444903108 ----------------------------------------------------------------- (CUSIP Number) Check the following box if a fee is being paid with this statement [ ]. (A fee is not required only if the reporting person: (1) has a previous statement on file reporting beneficial ownership of more than five percent of the class of securities described in Item 1; and (2) has filed no amendment subsequent thereto reporting beneficial ownership of five percent or less of such class.) (See Rule 13d-7.) *The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page. The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). (Continued on following page(s)) Page 1 of 14 pages -- -- CUSIP No. 444903108 13G Page 2 of 14 pages ------------ ----- ----- ------------------------------------------------------------------- 1. NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON HealthCare Ventures III, L.P. ------------------------------------------------------------------- 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] ------------------------------------------------------------------- 3. SEC USE ONLY ------------------------------------------------------------------- 4. CITIZENSHIP OR PLACE OF ORGANIZATION Delaware ------------------------------------------------------------------- 5. SOLE VOTING POWER ----------------------------------------------- NUMBER OF 6. SHARED VOTING POWER SHARES BENEFICIALLY 198,106 OWNED BY ----------------------------------------------- EACH 7. SOLE DISPOSITIVE POWER REPORTING PERSON WITH ----------------------------------------------- 8. SHARED DISPOSITIVE POWER 198,106 ------------------------------------------------------------------- 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 198,106 ------------------------------------------------------------------- 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] ------------------------------------------------------------------- 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 1.1% ------------------------------------------------------------------- 12. TYPE OF REPORTING PERSON* PN ------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT! CUSIP No. 444903108 13G Page 3 of 14 pages ------------ ----- ----- ------------------------------------------------------------------- 1. NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON HealthCare Partners III, L.P. ------------------------------------------------------------------- 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] ------------------------------------------------------------------- 3. SEC USE ONLY ------------------------------------------------------------------- 4. CITIZENSHIP OR PLACE OF ORGANIZATION Delaware ------------------------------------------------------------------- 5. SOLE VOTING POWER ----------------------------------------------- NUMBER OF 6. SHARED VOTING POWER SHARES BENEFICIALLY 198,106 OWNED BY ----------------------------------------------- EACH 7. SOLE DISPOSITIVE POWER REPORTING PERSON WITH ----------------------------------------------- 8. SHARED DISPOSITIVE POWER 198,106 ------------------------------------------------------------------- 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 198,106 ------------------------------------------------------------------- 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] ------------------------------------------------------------------- 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 1.1% ------------------------------------------------------------------- 12. TYPE OF REPORTING PERSON* PN ------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT! CUSIP No. 444903108 13G Page 4 of 14 pages ------------ ----- ----- ------------------------------------------------------------------- 1. NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON HealthCare Ventures IV, L.P. ------------------------------------------------------------------- 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] ------------------------------------------------------------------- 3. SEC USE ONLY ------------------------------------------------------------------- 4. CITIZENSHIP OR PLACE OF ORGANIZATION Delaware ------------------------------------------------------------------- 5. SOLE VOTING POWER ----------------------------------------------- NUMBER OF 6. SHARED VOTING POWER SHARES BENEFICIALLY 58,061 OWNED BY ----------------------------------------------- EACH 7. SOLE DISPOSITIVE POWER REPORTING PERSON WITH ----------------------------------------------- 8. SHARED DISPOSITIVE POWER 58,061 ------------------------------------------------------------------- 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 58,061 ------------------------------------------------------------------- 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] ------------------------------------------------------------------- 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 .3% ------------------------------------------------------------------- 12. TYPE OF REPORTING PERSON* PN ------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT! CUSIP No. 444903108 13G Page 5 of 14 pages ------------ ----- ----- ------------------------------------------------------------------- 1. NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON HealthCare Partners IV, L.P. ------------------------------------------------------------------- 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] ------------------------------------------------------------------- 3. SEC USE ONLY ------------------------------------------------------------------- 4. CITIZENSHIP OR PLACE OF ORGANIZATION Delaware ------------------------------------------------------------------- 5. SOLE VOTING POWER ----------------------------------------------- NUMBER OF 6. SHARED VOTING POWER SHARES BENEFICIALLY 58,061 OWNED BY ----------------------------------------------- EACH 7. SOLE DISPOSITIVE POWER REPORTING PERSON WITH ----------------------------------------------- 8. SHARED DISPOSITIVE POWER 58,061 ------------------------------------------------------------------- 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 58,061 ------------------------------------------------------------------- 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] ------------------------------------------------------------------- 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 .3% ------------------------------------------------------------------- 12. TYPE OF REPORTING PERSON* PN ------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT! CUSIP No. 444903108 13G Page 6 of 14 pages ------------ ----- ----- ------------------------------------------------------------------- 1. NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON James H. Cavanaugh, Ph.D. ------------------------------------------------------------------- 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] ------------------------------------------------------------------- 3. SEC USE ONLY ------------------------------------------------------------------- 4. CITIZENSHIP OR PLACE OF ORGANIZATION United States ------------------------------------------------------------------- 5. SOLE VOTING POWER 81,914 ----------------------------------------------- NUMBER OF 6. SHARED VOTING POWER SHARES BENEFICIALLY 256,167 OWNED BY ----------------------------------------------- EACH 7. SOLE DISPOSITIVE POWER REPORTING PERSON 81,914 WITH ----------------------------------------------- 8. SHARED DISPOSITIVE POWER 256,167 ------------------------------------------------------------------- 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 338,081 ------------------------------------------------------------------- 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] ------------------------------------------------------------------- 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 1.8% ------------------------------------------------------------------- 12. TYPE OF REPORTING PERSON* IN ------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT! CUSIP No. 444903108 13G Page 7 of 14 pages ------------ ----- ----- ------------------------------------------------------------------- 1. NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON Harold R. Werner ------------------------------------------------------------------- 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] ------------------------------------------------------------------- 3. SEC USE ONLY ------------------------------------------------------------------- 4. CITIZENSHIP OR PLACE OF ORGANIZATION United States ------------------------------------------------------------------- 5. SOLE VOTING POWER 21,474 ----------------------------------------------- NUMBER OF 6. SHARED VOTING POWER SHARES BENEFICIALLY 256,167 OWNED BY ----------------------------------------------- EACH 7. SOLE DISPOSITIVE POWER REPORTING PERSON 21,474 WITH ----------------------------------------------- 8. SHARED DISPOSITIVE POWER 256,167 ------------------------------------------------------------------- 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 277,641 ------------------------------------------------------------------- 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] ------------------------------------------------------------------- 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 1.5% ------------------------------------------------------------------- 12. TYPE OF REPORTING PERSON* IN ------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT! CUSIP No. 444903108 13G Page 8 of 14 pages ------------ ----- ----- ------------------------------------------------------------------- 1. NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON John W. Littlechild ------------------------------------------------------------------- 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] ------------------------------------------------------------------- 3. SEC USE ONLY ------------------------------------------------------------------- 4. CITIZENSHIP OR PLACE OF ORGANIZATION United States ------------------------------------------------------------------- 5. SOLE VOTING POWER 44,960 ----------------------------------------------- NUMBER OF 6. SHARED VOTING POWER SHARES BENEFICIALLY 256,167 OWNED BY ----------------------------------------------- EACH 7. SOLE DISPOSITIVE POWER REPORTING PERSON 44,960 WITH ----------------------------------------------- 8. SHARED DISPOSITIVE POWER 256,167 ------------------------------------------------------------------- 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 301,127 ------------------------------------------------------------------- 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] ------------------------------------------------------------------- 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 1.6% ------------------------------------------------------------------- 12. TYPE OF REPORTING PERSON* IN ------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT! CUSIP No. 444903108 13G Page 9 of 14 pages ------------ ----- ----- ------------------------------------------------------------------- 1. NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON William Crouse ------------------------------------------------------------------- 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] ------------------------------------------------------------------- 3. SEC USE ONLY ------------------------------------------------------------------- 4. CITIZENSHIP OR PLACE OF ORGANIZATION United States ------------------------------------------------------------------- 5. SOLE VOTING POWER 29,414 ----------------------------------------------- NUMBER OF 6. SHARED VOTING POWER SHARES BENEFICIALLY 256,167 OWNED BY ----------------------------------------------- EACH 7. SOLE DISPOSITIVE POWER REPORTING PERSON 29,414 WITH ----------------------------------------------- 8. SHARED DISPOSITIVE POWER 256,167 ------------------------------------------------------------------- 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 285,581 ------------------------------------------------------------------- 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] ------------------------------------------------------------------- 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 1.5% ------------------------------------------------------------------- 12. TYPE OF REPORTING PERSON* IN ------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT! Page 10 of 14 pages ----- ----- Item 1. (a) Name of Issuer: Human Genome Sciences, Inc. (b) Address of Issuer's Principal Executive Offices: 9620 Medical Center Drive Rockville, Maryland 20850-3338 Item 2. (a) Name of Person Filing: HealthCare Ventures III, L.P. ("HCV III"), HealthCare Partners III, L.P. ("HCP III"), HealthCare Ventures IV, L.P. ("HCV IV"), HealthCare Partners IV, L.P. ("HCP IV"), Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse. See attached Exhibit A which is a copy of their agreement in writing to file this statement on behalf of each of them.(1) (b) Address of Principal Business Office or, if none, Residence: The business address for HCV III, HCP III, HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner and Crouse is Twin Towers at Metro Park, 379 Thornall Street, Edison, New Jersey 08837. The business address for Mr. Littlechild is One Kendall Square, Building 300, Cambridge, Massachusetts 02139. (c) Citizenship: HCV III, HCP III, HCV IV and HCP IV are limited partnerships organized under the laws of the State of Delaware. Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse are each United States citizens. (d) Title of Class of Securities: Common Stock, par value $.01 ("Shares"). - -------- (1) Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse are general partners of HCP III and HCP IV, which are the general partners of HCV III and HCV IV, respectively, the record holder of Issuer's securities. Page 11 of 14 pages ----- ----- (e) CUSIP Number: 444903108 Item 3. If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b), check whether the person filing is a: Inapplicable. Item 4. Ownership. (a) Amount Beneficially Owned: As of December 31, 1996: HCV III and HCP III beneficially owned 198,106 Shares of Issuer's Common Stock; HCV IV and HCP IV beneficially owned 58,061 Shares of Issuer's Common Stock; and each of Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse each beneficially owned 388,081, 277,641, 301,127 and 285,581 Shares of Issuer's Common Stock, respectively. (b) Percent of Class: As of December 31, 1996: the 198,106 Shares of Issuer's securities beneficially owned by HCV III and HCP III constitute 1.1% of Issuer's Shares outstanding; the 58,061 Shares of Issuer's securities beneficially owned by HCV IV and HCP IV constitute 0.3% of Issuer's Shares outstanding; and the 388,081, 277,641, 301,127 and 285,581 Shares of Issuer's securities beneficially owned by each of Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse constitute 1.8%, 1.5%, 1.6% and 1.5%, respectively, of Issuer's Shares outstanding. (c) Number of shares as to which such person has: (i) sole power to vote or to direct the vote: Each of Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse has the sole power to vote or direct the vote of the 81,914, 21,474, 44,960 and 29,414 Shares, respectively, of Issuer's Common Stock beneficially owned by him. (ii) shared power to vote or to direct the vote: HCV III, HCP III, Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse share the power to vote or direct the vote of those Shares owned by HCV III. Page 12 of 14 pages ----- ----- HCV IV, HCP IV Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse share the power to vote or to direct the vote of those Shares owned by HCV IV. (iii) sole power to dispose or to direct the disposition of: Each of Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse has the sole power to dispose or direct the disposition of the 81,914, 21,474, 44,960 and 29,414 Shares, respectively, of Issuer's Common Stock beneficially owned by him. (iv) shared power to dispose of or to direct the disposition of: HCV III, HCP III, Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse share the power to dispose of or direct the disposition of those Shares owned by HCV III. HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse share the power to dispose of or to direct the disposition of those Shares owned by HCV IV. Item 5. Ownership of Five Percent or less of a Class: If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the Class of Securities, check the following [X]. Item 6. Ownership of More than Five Percent on Behalf of Another Person: Inapplicable. Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company: Inapplicable. Item 8. Identification and Classification of Members of the Group: Inapplicable. Item 9. Notice of Dissolution of Group: Inapplicable. Item 10. Certification: Inapplicable. Page 13 of 14 pages ----- ----- SIGNATURES After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. Dated: February 13, 1997 HealthCare Ventures III, L.P., Edison, New Jersey by its General Partner, HealthCare Partners III, L.P. By: /s/ Jeffrey Steinberg ----------------------------- Administrative Partner Dated: February 13, 1997 HealthCare Partners III, L.P. Edison, New Jersey By: /s/ Jeffrey Steinberg ----------------------------- Administrative Partner Dated: February 13, 1997 HealthCare Ventures IV, L.P., Edison, New Jersey by its General Partner, HealthCare Partners IV, L.P. By: /s/ Jeffrey Steinberg ----------------------------- Administrative Partner Dated: February 13, 1997 HealthCare Partners IV, L.P. Edison, New Jersey By: /s/ Jeffrey Steinberg ----------------------------- Administrative Partner Dated: February 13, 1997 By: /s/ Jeffrey Steinberg as Attorney-in-Fact Edison, New Jersey ----------------------------- James H. Cavanaugh, Ph.D. Dated: February 13, 1997 By: /s/ Jeffrey Steinberg as Attorney-in-Fact Edison, New Jersey ----------------------------- Harold R. Werner Dated: February 13, 1997 By: /s/ Jeffrey Steinberg as Attorney-in-Fact Cambridge, ----------------------------- Massachusetts John W. Littlechild Dated: February 13, 1997 By: /s/ Jeffrey Steinberg as Attorney-in-Fact Edison, New Jersey ----------------------------- William Crouse
Page 14 of 14 pages ----- ----- EXHIBIT A AGREEMENT JOINT FILING OF SCHEDULE 13G The undersigned hereby agree to jointly prepare and file with regulatory authorities a Schedule 13G and any future amendments thereto reporting each of the undersigned's ownership of securities of Human Genome Sciences, Inc. and hereby affirm that such Schedule 13G is being filed on behalf of each of the undersigned. Dated: February 13, 1997 HealthCare Ventures III, L.P., Edison, New Jersey by its General Partner, HealthCare Partners III, L.P. By: /s/ Jeffrey Steinberg ----------------------------- Administrative Partner Dated: February 13, 1997 HealthCare Partners III, L.P. Edison, New Jersey By: /s/ Jeffrey Steinberg ----------------------------- Administrative Partner Dated: February 13, 1997 HealthCare Ventures IV, L.P., Edison, New Jersey by its General Partner, HealthCare Partners IV, L.P. By: /s/ Jeffrey Steinberg ----------------------------- Administrative Partner Dated: February 13, 1997 HealthCare Partners IV, L.P. Edison, New Jersey By: /s/ Jeffrey Steinberg ----------------------------- Administrative Partner Dated: February 13, 1997 By: /s/ Jeffrey Steinberg as Attorney-in-Fact Edison, New Jersey ----------------------------- James H. Cavanaugh, Ph.D. Dated: February 13, 1997 By: /s/ Jeffrey Steinberg as Attorney-in-Fact Edison, New Jersey ----------------------------- Harold R. Werner Dated: February 13, 1997 By: /s/ Jeffrey Steinberg as Attorney-in-Fact Cambridge, ----------------------------- Massachusetts John W. Littlechild Dated: February 13, 1997 By: /s/ Jeffrey Steinberg as Attorney-in-Fact Edison, New Jersey ----------------------------- William Crouse
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